The 7 Best Supplements for Men Over 40

Many men over 40 look for supplements to fill nutritional gaps or boost aging bodies.

While no pill replaces a healthy diet, certain nutrients are worth considering:

Protein Powder

As building muscle becomes slightly harder with age, extra protein helps. A whey or plant protein powder can easily top up your intake for muscle repair and bone strength .

Vitamin D3 (with Calcium)

Vitamin D supports bone health, immune function, and even testosterone production. Nearly 35% of Americans are deficient in D3 . Especially if you work indoors or live in a cloudy climate, supplement D3 (1,000–2,000 IU/day) alongside calcium for bones .

Omega-3 Fish Oil

Omega-3 fatty acids reduce inflammation, support heart and brain health, and even ease joint stiffness. They are essential in our diet but often under-consumed. Omega-3s “soothe your joints” and aid cognitive function, making them especially beneficial after 40 . Aim for a supplement with EPA/DHA (around 1,000 mg combined daily).

Multivitamin

A high-quality multivitamin ensures you’re not missing basic nutrients. Look for one containing vitamin A, C, D3, E, the B-complex (especially B6 and B12), magnesium, zinc and boron – these support metabolism, energy, and hormonal health . It’s a safety net for days when diet isn’t perfect.

Vitamin B12

Absorption of B12 often declines with age. B12 supports energy levels and cognitive health, so many men over 40 supplement it. Studies note that many older adults have marginal B12 levels unless supplemented . A sublingual or chewable B12 (500 mcg weekly or 1,000 mcg daily) is easy to take.

Magnesium

This mineral is crucial for muscle function, sleep quality, and even testosterone. Low magnesium is linked to heart issues, high blood pressure and inflammation. Consider magnesium citrate or glycinate (200–400 mg at night) to help you sleep and recover.

 
Creatine 

Creatine is one of the most effective supplements for men in their 40’s, supporting both muscle and brain health. As natural creatine stores decline with age, it helps maintain strength, lean muscle, and recovery while also fuelling the brain to improve memory, mental clarity, and protect against age related decline, keeping men stronger, sharper, and more resilient. (5-20g doses have been proven to have benefits.)

Remember

Supplements should “supplement” a good diet, not replace it. Before starting any new supplement, consider discussing with your doctor (especially vitamin D dosing or if you take medications). But for most men over 40, these seven cover the major bases of muscle, bone, heart and hormonal support.